Life-threatening motor neurotoxicity in association with bortezomib.

Gupta, Sunil; Pagliuca, Antonio; Devereux, Steve; Mufti, Ghulam J; Schey, Steve

Gupta, Sunil; Pagliuca, Antonio; Devereux, Steve; Mufti, Ghulam J; Schey, Steve.

Haematologica ; 91(7): 1001, 2006 Jul.

Article in En | MEDLINE | ID: mdl-16757419

ABSTRACT

ABSTRACT

Bortezomib has been licensed to be used in relapsed and refractory multiple myeloma. It is a promising agent for this incurable condition but our effort is to caution hematologists about the life-threatening neurotoxicity (grade 4) which was seen in two of six patients treated with this agent although the complication cannot definitely be attributed to bortezomib.

Subject(s)

Boronic Acids/adverse effects; Neurotoxicity Syndromes/etiology; Pyrazines/adverse effects; Aged; Bortezomib; Critical Illness; Female; Humans; Middle Aged; Multiple Myeloma/complications; Multiple Myeloma/drug therapy; Peripheral Nervous System Diseases/chemically induced

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Boronic Acids / Neurotoxicity Syndromes Type of study: Risk_factors_studies Limits: Aged / Female / Humans / Middle aged Language: En Journal: Haematologica Year: 2006 Type: Article

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