A randomised trial to compare the pharmacokinetic, pharmacodynamic, and antiviral effects of peginterferon alfa-2b and peginterferon alfa-2a in patients with chronic hepatitis C (COMPARE).

Silva, Marcelo; Poo, Jorge; Wagner, Frank; Jackson, Mary; Cutler, David; Grace, Michael; Bordens, Ronald; Cullen, Connie; Harvey, Joann; Laughlin, Mark

Silva, Marcelo; Poo, Jorge; Wagner, Frank; Jackson, Mary; Cutler, David; Grace, Michael; Bordens, Ronald; Cullen, Connie; Harvey, Joann; Laughlin, Mark.

Affiliation

Silva M; Hospital Universitario Austral, Pilar, Argentina.

J Hepatol ; 45(2): 204-13, 2006 Aug.

Article in En | MEDLINE | ID: mdl-16780997

Subject(s)

Antiviral Agents/pharmacokinetics; Hepatitis C, Chronic/blood; Hepatitis C, Chronic/drug therapy; Interferon-alpha/pharmacokinetics; Polyethylene Glycols/pharmacokinetics; Adolescent; Adult; Aged; Antiviral Agents/therapeutic use; Double-Blind Method; Drug Carriers; Drug Therapy, Combination; Female; Follow-Up Studies; Hepacivirus/drug effects; Hepacivirus/genetics; Hepatitis C, Chronic/virology; Humans; Interferon alpha-2; Interferon-alpha/therapeutic use; Male; Middle Aged; Polyethylene Glycols/therapeutic use; Polymerase Chain Reaction; RNA, Viral/analysis; Recombinant Proteins; Ribavirin/pharmacokinetics; Ribavirin/therapeutic use; Treatment Outcome; Viral Load

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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Polyethylene Glycols / Interferon-alpha / Hepatitis C, Chronic Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Hepatol Journal subject: GASTROENTEROLOGIA Year: 2006 Type: Article Affiliation country: Argentina

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