Inhibition of 26S proteasome activity by huntingtin filaments but not inclusion bodies isolated from mouse and human brain.

Díaz-Hernández, Miguel; Valera, Adriana G; Morán, María A; Gómez-Ramos, Pilar; Alvarez-Castelao, Beatriz; Castaño, José G; Hernández, Félix; Lucas, José J

Díaz-Hernández, Miguel; Valera, Adriana G; Morán, María A; Gómez-Ramos, Pilar; Alvarez-Castelao, Beatriz; Castaño, José G; Hernández, Félix; Lucas, José J.

Affiliation

Díaz-Hernández M; Centro de Biología Molecular Severo Ochoa, CSIC/UAM, Madrid, Spain.

J Neurochem ; 98(5): 1585-96, 2006 Sep.

Article in En | MEDLINE | ID: mdl-16787406

Subject(s)

Huntington Disease/metabolism; Proteasome Endopeptidase Complex/metabolism; Serotonin Plasma Membrane Transport Proteins/chemistry; Serotonin Plasma Membrane Transport Proteins/genetics; Aged; Aged, 80 and over; Animals; Coumarins/pharmacology; Dose-Response Relationship, Drug; Female; Flow Cytometry/methods; Humans; Huntington Disease/pathology; Inclusion Bodies/metabolism; Inclusion Bodies/pathology; Inclusion Bodies/ultrastructure; Male; Mice; Mice, Transgenic; Microscopy, Atomic Force; Microscopy, Immunoelectron/methods; Mutation/physiology; Oligopeptides/pharmacology; Peptides; Time Factors; Ubiquitin/chemistry; Ubiquitin/genetics; Ubiquitin/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Huntington Disease / Proteasome Endopeptidase Complex / Serotonin Plasma Membrane Transport Proteins Type of study: Prognostic_studies Limits: Aged / Aged80 / Animals / Female / Humans / Male Language: En Journal: J Neurochem Year: 2006 Type: Article Affiliation country: Spain

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