Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression.

Mann, Jason R; Backlund, Michael G; Buchanan, F Gregory; Daikoku, Taki; Holla, Vijaykumar R; Rosenberg, Daniel W; Dey, Sudhansu K; DuBois, Raymond N

Mann, Jason R; Backlund, Michael G; Buchanan, F Gregory; Daikoku, Taki; Holla, Vijaykumar R; Rosenberg, Daniel W; Dey, Sudhansu K; DuBois, Raymond N.

Affiliation

Mann JR; Departments of Cell and Developmental Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 2300 Pierce Avenue, Nashville, TN 37232, USA.

Cancer Res ; 66(13): 6649-56, 2006 Jul 01.

Article in En | MEDLINE | ID: mdl-16818638

Subject(s)

Colorectal Neoplasms/metabolism; Colorectal Neoplasms/pathology; Dinoprostone/metabolism; Epidermal Growth Factor/pharmacology; Hydroxyprostaglandin Dehydrogenases/biosynthesis; Transcription Factors/biosynthesis; Animals; Colorectal Neoplasms/enzymology; Colorectal Neoplasms/genetics; Disease Progression; Down-Regulation/drug effects; ErbB Receptors/metabolism; HCT116 Cells; HT29 Cells; Humans; Hydroxyprostaglandin Dehydrogenases/genetics; Mice; Mice, Inbred C57BL; Snail Family Transcription Factors; Transcription Factors/genetics; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Colorectal Neoplasms / Dinoprostone / Hydroxyprostaglandin Dehydrogenases / Epidermal Growth Factor Limits: Animals / Humans Language: En Journal: Cancer Res Year: 2006 Type: Article Affiliation country: United States

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