Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models.

Tafi, Andrea; Bernardini, Cesare; Botta, Maurizio; Corelli, Federico; Andreini, Matteo; Martinelli, Adriano; Ortore, Gabriella; Baraldi, Pier Giovanni; Fruttarolo, Francesca; Borea, Pier Andrea; Tuccinardi, Tiziano

Tafi, Andrea; Bernardini, Cesare; Botta, Maurizio; Corelli, Federico; Andreini, Matteo; Martinelli, Adriano; Ortore, Gabriella; Baraldi, Pier Giovanni; Fruttarolo, Francesca; Borea, Pier Andrea; Tuccinardi, Tiziano.

Affiliation

Tafi A; Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy.

J Med Chem ; 49(14): 4085-97, 2006 Jul 13.

Article in En | MEDLINE | ID: mdl-16821770

Subject(s)

Adenosine A3 Receptor Antagonists; Models, Molecular; Receptor, Adenosine A3/chemistry; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Drug Design; Furans/chemical synthesis; Furans/chemistry; Furans/pharmacology; Humans; Molecular Structure; Pyrazoles/chemical synthesis; Pyrazoles/chemistry; Pyrazoles/pharmacology; Pyrimidines/chemical synthesis; Pyrimidines/chemistry; Pyrimidines/pharmacology; Radioligand Assay; Thermodynamics; Triazoles/chemical synthesis; Triazoles/chemistry; Triazoles/pharmacology

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Models, Molecular / Receptor, Adenosine A3 / Adenosine A3 Receptor Antagonists Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2006 Type: Article Affiliation country: Italy

Search on Google

XML

PubMed Links