Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain.

Lopez-Santiago, Luis F; Pertin, Marie; Morisod, Xavier; Chen, Chunling; Hong, Shuangsong; Wiley, John; Decosterd, Isabelle; Isom, Lori L

Lopez-Santiago, Luis F; Pertin, Marie; Morisod, Xavier; Chen, Chunling; Hong, Shuangsong; Wiley, John; Decosterd, Isabelle; Isom, Lori L.

Affiliation

Lopez-Santiago LF; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109-0632, USA.

J Neurosci ; 26(30): 7984-94, 2006 Jul 26.

Article in En | MEDLINE | ID: mdl-16870743

Subject(s)

Ganglia, Spinal/physiology; Ion Channel Gating/physiology; Nerve Tissue Proteins/metabolism; Neurons/physiology; Pain Threshold/physiology; Sodium Channels/metabolism; Tetrodotoxin/administration & dosage; Adaptation, Physiological/drug effects; Adaptation, Physiological/physiology; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Ganglia, Spinal/drug effects; Ion Channel Gating/drug effects; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons/drug effects; Pain Threshold/drug effects; Voltage-Gated Sodium Channel beta-2 Subunit

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetrodotoxin / Sodium Channels / Ion Channel Gating / Pain Threshold / Ganglia, Spinal / Nerve Tissue Proteins / Neurons Type of study: Diagnostic_studies Limits: Animals Language: En Journal: J Neurosci Year: 2006 Type: Article Affiliation country: United States

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