Prion protein gene M129 allele is a risk factor for Alzheimer's disease.
J Neural Transm (Vienna)
; 113(11): 1747-51, 2006 Nov.
Article
in En
| MEDLINE
| ID: mdl-16897605
ABSTRACT
Prion protein gene polymorphism M129V represents a known risk factor for Creutzfeldt-Jakob disease. Recently, the meta-analysis revealed that homozygosity at codon 129 is connected with increased risk of Alzheimer's disease (AD). To determine whether M129V polymorphism is a risk factor for AD we analyzed a group of early-onset, and late-onset Polish AD patients. We observed that in LOAD patients there is a statistically significant increase of MM (p=0.0028) and decrease of MV (p=0.0006) genotype frequency, as compared to controls. When both groups were stratified according to APOE4 status, increase of MM and decrease of MV genotype frequency were significant in the LOAD subgroup with no APOE4 (p=0.017, and p=0.018, respectively). In the subgroup with APOE4 allele, only MV genotype frequency was significantly lower, as compared to controls (p=0.035). However, no interaction was found between APOE4 status and M129V polymorphism. We conclude that MM genotype increases LOAD risk in Polish population independently from the APOE4 status.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prions
/
Genetic Predisposition to Disease
/
Alleles
/
Alzheimer Disease
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
J Neural Transm (Vienna)
Year:
2006
Type:
Article
Affiliation country:
Poland