NMR-based quality control approach for the identification of false positives and false negatives in high throughput screening.

Dalvit, Claudio; Caronni, Dannica; Mongelli, Nicola; Veronesi, Marina; Vulpetti, Anna

Dalvit, Claudio; Caronni, Dannica; Mongelli, Nicola; Veronesi, Marina; Vulpetti, Anna.

Affiliation

Dalvit C; Chemistry Department Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano, Milan, Italy. claudio.dalvit@nervianoms.com

Curr Drug Discov Technol ; 3(2): 115-24, 2006 Jun.

Article in En | MEDLINE | ID: mdl-16925519

Subject(s)

Enzyme Inhibitors/chemistry; Magnetic Resonance Spectroscopy/methods; Technology, Pharmaceutical/methods; Algorithms; Dose-Response Relationship, Drug; Enzyme Inhibitors/pharmacology; Enzyme Inhibitors/standards; Humans; Inhibitory Concentration 50; Isoquinolines/chemistry; Isoquinolines/pharmacology; Molecular Structure; Protein Serine-Threonine Kinases/antagonists & inhibitors; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Proto-Oncogene Proteins c-akt/metabolism; Quality Control; Quercetin/chemistry; Quercetin/pharmacology; Solubility; Structure-Activity Relationship; Sulfonamides/chemistry; Sulfonamides/pharmacology; Technology, Pharmaceutical/trends; Thymidine Phosphorylase/antagonists & inhibitors; Thymidine Phosphorylase/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Magnetic Resonance Spectroscopy / Technology, Pharmaceutical / Enzyme Inhibitors Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: Curr Drug Discov Technol Journal subject: FARMACOLOGIA Year: 2006 Type: Article Affiliation country: Italy

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