Designed ATRA analogue active against ATRA-resistant acute promyelocytic leukemia cells having a single nucleotide substitution in their retinoic acid receptor.

Komura, Naoyuki; Ikeda, Yoko; Masuda, Natsuko; Umezawa, Yoji; Ito, Keisuke; Kizaki, Masahiro; Umezawa, Kazuo

Komura, Naoyuki; Ikeda, Yoko; Masuda, Natsuko; Umezawa, Yoji; Ito, Keisuke; Kizaki, Masahiro; Umezawa, Kazuo.

Affiliation

Komura N; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-0061, Japan.

Leuk Res ; 31(3): 301-13, 2007 Mar.

Article in En | MEDLINE | ID: mdl-16968653

Subject(s)

Leukemia, Promyelocytic, Acute/drug therapy; Leukemia, Promyelocytic, Acute/genetics; Point Mutation; Receptors, Retinoic Acid/genetics; Tretinoin/chemistry; Tretinoin/pharmacology; Apoptosis/drug effects; CD11b Antigen/biosynthesis; CD11b Antigen/drug effects; Cell Differentiation/drug effects; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21/biosynthesis; Cyclin-Dependent Kinase Inhibitor p21/drug effects; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Genetic Therapy/methods; HL-60 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Leukemia, Promyelocytic, Acute/pathology; Molecular Structure; Oligonucleotide Array Sequence Analysis/methods; Reactive Oxygen Species/metabolism; Receptors, Retinoic Acid/drug effects; Retinoic Acid Receptor alpha; Structure-Activity Relationship; Tretinoin/analogs & derivatives; bcl-2-Associated X Protein/biosynthesis; bcl-2-Associated X Protein/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Tretinoin / Leukemia, Promyelocytic, Acute / Point Mutation / Receptors, Retinoic Acid Limits: Humans Language: En Journal: Leuk Res Year: 2007 Type: Article Affiliation country: Japan

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