Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation.

Hartman, Amy D; Wilson-Weekes, Annique; Suvannasankha, Attaya; Burgess, Gem S; Phillips, Carissa A; Hincher, Katie J; Cripe, Larry D; Boswell, H Scott

Hartman, Amy D; Wilson-Weekes, Annique; Suvannasankha, Attaya; Burgess, Gem S; Phillips, Carissa A; Hincher, Katie J; Cripe, Larry D; Boswell, H Scott.

Affiliation

Hartman AD; Walther Cancer Institute, Indianapolis, IN 46202, USA.

Exp Hematol ; 34(10): 1360-76, 2006 Oct.

Article in En | MEDLINE | ID: mdl-16982329

Subject(s)

Cell Proliferation; Leukemia, Myeloid, Acute/enzymology; Mitogen-Activated Protein Kinase 8/metabolism; Signal Transduction; fms-Like Tyrosine Kinase 3/metabolism; Apoptosis/drug effects; Apoptosis/genetics; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Cell Survival/genetics; Enzyme Activation/drug effects; Enzyme Activation/genetics; Fusion Proteins, bcr-abl/metabolism; Gene Expression Regulation, Enzymologic/drug effects; Gene Expression Regulation, Enzymologic/genetics; Gene Expression Regulation, Leukemic/drug effects; Gene Expression Regulation, Leukemic/genetics; Humans; Leukemia, Myeloid, Acute/genetics; Mutation; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-cbl/metabolism; Quantitative Trait Loci/genetics; RNA, Small Interfering/genetics; RNA, Small Interfering/pharmacology; Signal Transduction/drug effects; Signal Transduction/genetics; Tumor Suppressor Protein p14ARF/metabolism; Tumor Suppressor Protein p53/metabolism; fms-Like Tyrosine Kinase 3/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Signal Transduction / Mitogen-Activated Protein Kinase 8 / Cell Proliferation / Fms-Like Tyrosine Kinase 3 Type of study: Prognostic_studies Limits: Humans Language: En Journal: Exp Hematol Year: 2006 Type: Article Affiliation country: United States

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