Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura.

Schrump, David S; Fischette, Maria R; Nguyen, Dao M; Zhao, Ming; Li, Xinmin; Kunst, Tricia F; Hancox, Ana; Hong, Julie A; Chen, G Aaron; Pishchik, Vitaliy; Figg, William D; Murgo, Anthony J; Steinberg, Seth M

Schrump, David S; Fischette, Maria R; Nguyen, Dao M; Zhao, Ming; Li, Xinmin; Kunst, Tricia F; Hancox, Ana; Hong, Julie A; Chen, G Aaron; Pishchik, Vitaliy; Figg, William D; Murgo, Anthony J; Steinberg, Seth M.

Affiliation

Schrump DS; Thoracic Oncology Section Surgery Branch, Cancer Therapy Evaluation Program, National Cancer Institute/NIH, 10 Center Drive, Bethesda, MD 20892, USA. davidschrump@nih.gov

Clin Cancer Res ; 12(19): 5777-85, 2006 Oct 01.

Article in En | MEDLINE | ID: mdl-17020984

Subject(s)

Antimetabolites, Antineoplastic/pharmacology; Azacitidine/analogs & derivatives; Esophageal Neoplasms/genetics; Gene Expression Regulation, Neoplastic/drug effects; Lung Neoplasms/genetics; Pleural Neoplasms/genetics; Adult; Aged; Antigens, Neoplasm/genetics; Antigens, Neoplasm/metabolism; Azacitidine/pharmacology; Carcinoma, Non-Small-Cell Lung/drug therapy; Carcinoma, Non-Small-Cell Lung/genetics; Carcinoma, Non-Small-Cell Lung/metabolism; Carcinoma, Squamous Cell/drug therapy; Carcinoma, Squamous Cell/genetics; Carcinoma, Squamous Cell/metabolism; DNA Modification Methylases/antagonists & inhibitors; Decitabine; Esophageal Neoplasms/drug therapy; Esophageal Neoplasms/metabolism; Female; Genes, p16/physiology; Humans; Lung Neoplasms/drug therapy; Lung Neoplasms/metabolism; Male; Maximum Tolerated Dose; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mesothelioma/drug therapy; Mesothelioma/genetics; Mesothelioma/metabolism; Middle Aged; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; Pleural Neoplasms/drug therapy; Pleural Neoplasms/metabolism; Transcriptional Activation

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Collection: 01-internacional Database: MEDLINE Main subject: Pleural Neoplasms / Azacitidine / Esophageal Neoplasms / Gene Expression Regulation, Neoplastic / Lung Neoplasms / Antimetabolites, Antineoplastic Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2006 Type: Article Affiliation country: United States

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