A case of an inflammatory myofibroblastic tumor in the lung which expressed TPM3-ALK gene fusion.
Pediatr Surg Int
; 23(6): 595-9, 2007 Jun.
Article
in En
| MEDLINE
| ID: mdl-17063337
ABSTRACT
We herein describe a 4-year-old boy who after being treated for pneumonia showed an abnormal shadow at the hilus of the right lung on chest X-rays with continued inflammatory findings in his laboratory data. CT and MR investigations suggested the existence of a neoplasm at that site. An open biopsy was thus performed for a definite diagnosis. The histological findings and the expression of TPM3-ALK fusion gene confirmed a diagnosis of an inflammatory myofibroblastic tumor. A right upper and middle lobectomy including the tumor was thus performed for a complete resection. In addition to the histological diagnosis, the detection of the tumor specific fusion gene provided objective evidence in making a diagnosis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tropomyosin
/
Protein-Tyrosine Kinases
/
Oncogene Proteins, Fusion
/
Lung Neoplasms
/
Neoplasms, Muscle Tissue
Limits:
Child, preschool
/
Humans
/
Male
Language:
En
Journal:
Pediatr Surg Int
Journal subject:
PEDIATRIA
Year:
2007
Type:
Article
Affiliation country:
Japan