Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function.

Funakoshi, Hajime; Chan, Tung O; Good, Julie C; Libonati, Joseph R; Piuhola, Jarkko; Chen, Xiongwen; MacDonnell, Scott M; Lee, Ling L; Herrmann, David E; Zhang, Jin; Martini, Jeffrey; Palmer, Timothy M; Sanbe, Atsushi; Robbins, Jeffrey; Houser, Steven R; Koch, Walter J; Feldman, Arthur M

Funakoshi, Hajime; Chan, Tung O; Good, Julie C; Libonati, Joseph R; Piuhola, Jarkko; Chen, Xiongwen; MacDonnell, Scott M; Lee, Ling L; Herrmann, David E; Zhang, Jin; Martini, Jeffrey; Palmer, Timothy M; Sanbe, Atsushi; Robbins, Jeffrey; Houser, Steven R; Koch, Walter J; Feldman, Arthur M.

Affiliation

Funakoshi H; Center for Translational Medicine, Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA.

Circulation ; 114(21): 2240-50, 2006 Nov 21.

Article in En | MEDLINE | ID: mdl-17088462

Subject(s)

Cardiomyopathy, Dilated/etiology; Cardiomyopathy, Dilated/physiopathology; Echocardiography; Heart/physiopathology; Myocardium/pathology; Receptor, Adenosine A1/metabolism; Animals; Cardiomegaly/etiology; Cardiomyopathy, Dilated/mortality; Cardiomyopathy, Dilated/pathology; Doxycycline/pharmacology; Electrocardiography; Fibrosis; Gene Expression; Heart Rate; Humans; Hypertension/etiology; Hypertension/metabolism; Mice; Mice, Transgenic; Phosphorylation; Proto-Oncogene Proteins c-akt/metabolism; Receptor, Adenosine A1/genetics; Survival Analysis; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Echocardiography / Cardiomyopathy, Dilated / Receptor, Adenosine A1 / Heart / Myocardium Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Circulation Year: 2006 Type: Article Affiliation country: United States

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