Effect of acetaminophen administration to rats chronically exposed to depleted uranium.

Guéguen, Y; Grandcolas, L; Baudelin, C; Grison, S; Tissandié, E; Jourdain, J R; Paquet, F; Voisin, P; Aigueperse, J; Gourmelon, P; Souidi, M

Guéguen, Y; Grandcolas, L; Baudelin, C; Grison, S; Tissandié, E; Jourdain, J R; Paquet, F; Voisin, P; Aigueperse, J; Gourmelon, P; Souidi, M.

Affiliation

Guéguen Y; Institute for Radiological Protection and Nuclear Safety, Radiological Protection and Human Health Division, Radiobiology and Epidemiology Department, Laboratory of Experimental Toxicology, Fontenay-aux-Roses, France. yann.gueguen@irsn.fr

Toxicology ; 229(1-2): 62-72, 2007 Jan 05.

Article in En | MEDLINE | ID: mdl-17126469

Subject(s)

Acetaminophen/administration & dosage; Environmental Exposure/adverse effects; Uranyl Nitrate/toxicity; Acetaminophen/blood; Alanine Transaminase/blood; Analgesics, Non-Narcotic/administration & dosage; Animals; Aspartate Aminotransferases/blood; Blood Urea Nitrogen; Creatinine/blood; Cytochrome P-450 Enzyme System/genetics; Cytochrome P-450 Enzyme System/metabolism; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic/drug effects; Gene Expression Regulation, Enzymologic/genetics; Injections, Intraperitoneal; Kidney/drug effects; Kidney/metabolism; Kidney/pathology; Liver/drug effects; Liver/metabolism; Liver/pathology; Male; Metabolic Detoxication, Phase I/genetics; Metabolic Detoxication, Phase II/genetics; Microsomes, Liver/drug effects; Microsomes, Liver/enzymology; Organ Size/drug effects; Radioactive Pollutants/blood; Radioactive Pollutants/toxicity; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Uranyl Nitrate/blood; Weight Loss/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Uranyl Nitrate / Environmental Exposure / Acetaminophen Type of study: Evaluation_studies Language: En Journal: Toxicology Year: 2007 Type: Article Affiliation country: France

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