Induction and characterization of monoclonal anti-idiotypic antibodies reactive with idiotopes of canine parvovirus neutralizing monoclonal antibodies.
Vet Immunol Immunopathol
; 29(1-2): 139-50, 1991 Aug.
Article
in En
| MEDLINE
| ID: mdl-1719693
ABSTRACT
Monoclonal anti-idiotypic (anti-Id) antibodies (Ab2) were generated against idiotypes (Id) of canine parvovirus (CPV) specific monoclonal antibodies (MoAbs). The binding of most of these anti-Id antibodies to their corresponding Id could be inhibited by antigen, thus classifying these anti-Id antibodies as Ab2 gamma or Ab2 beta. By inhibiting experiments it was shown that these anti-Id antibodies did not recognize interspecies cross-reactive idiotopes, but recognized private idiotopes, uniquely associated with the Id of the anti-CPV MoAb used for immunization. This classifies these anti-Id antibodies as non-internal image Ab2 gamma. The potential use of these non-internal image anti-Id antibodies for the induction of antiviral antibodies in the CPV system is discussed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parvoviridae
/
Antibodies, Anti-Idiotypic
/
Parvoviridae Infections
/
Dog Diseases
/
Antibodies, Monoclonal
/
Epitopes
Limits:
Animals
Language:
En
Journal:
Vet Immunol Immunopathol
Year:
1991
Type:
Article
Affiliation country:
Netherlands