Metabolism-based identification of a potent thrombin receptor antagonist.

Clasby, Martin C; Chackalamannil, Samuel; Czarniecki, Michael; Doller, Dario; Eagen, Keith; Greenlee, William; Kao, Grace; Lin, Yan; Tsai, Hsingan; Xia, Yan; Ahn, Ho-Sam; Agans-Fantuzzi, Jacqueline; Boykow, George; Chintala, Madhu; Foster, Carolyn; Smith-Torhan, April; Alton, Kevin; Bryant, Matthew; Hsieh, Yunsheng; Lau, Janice; Palamanda, Jairam

Clasby, Martin C; Chackalamannil, Samuel; Czarniecki, Michael; Doller, Dario; Eagen, Keith; Greenlee, William; Kao, Grace; Lin, Yan; Tsai, Hsingan; Xia, Yan; Ahn, Ho-Sam; Agans-Fantuzzi, Jacqueline; Boykow, George; Chintala, Madhu; Foster, Carolyn; Smith-Torhan, April; Alton, Kevin; Bryant, Matthew; Hsieh, Yunsheng; Lau, Janice; Palamanda, Jairam.

Affiliation

Clasby MC; Central Nervous System and Cardiovascular Chemical Research, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA.

J Med Chem ; 50(1): 129-38, 2007 Jan 11.

Article in En | MEDLINE | ID: mdl-17201416

Subject(s)

Furans/chemical synthesis; Heterocyclic Compounds, 3-Ring/chemical synthesis; Platelet Aggregation Inhibitors/chemical synthesis; Pyridines/chemical synthesis; Receptors, Thrombin/antagonists & inhibitors; Animals; Biological Availability; Cytochrome P-450 Enzyme System/biosynthesis; Furans/pharmacokinetics; Furans/pharmacology; Heterocyclic Compounds, 3-Ring/pharmacokinetics; Heterocyclic Compounds, 3-Ring/pharmacology; Humans; In Vitro Techniques; Macaca fascicularis; Microsomes, Liver/drug effects; Microsomes, Liver/enzymology; Platelet Aggregation/drug effects; Platelet Aggregation Inhibitors/pharmacokinetics; Platelet Aggregation Inhibitors/pharmacology; Pyridines/pharmacokinetics; Pyridines/pharmacology; Radioligand Assay; Rats; Stereoisomerism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Platelet Aggregation Inhibitors / Receptors, Thrombin / Furans / Heterocyclic Compounds, 3-Ring Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Type: Article Affiliation country: United States

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