Bordetella pertussis binds human C1 esterase inhibitor during the virulent phase, to evade complement-mediated killing.
J Infect Dis
; 195(4): 585-8, 2007 Feb 15.
Article
in En
| MEDLINE
| ID: mdl-17230419
ABSTRACT
C1 esterase inhibitor (C1inh) is a major inhibitor of several pathways of inflammation in humans. In this study, we show that virulent-phase cultures of Bordetella pertussis, the etiological agent for whooping cough, but not other Bordetella species specifically recruit C1inh from human serum. Using a spontaneous mutant of B. pertussis that was deficient in C1inh binding, we demonstrate that the ability of B. pertussis to acquire high levels of human C1inh and wild-type levels of serum resistance are well correlated, suggesting that, in addition to and independent of BrkA expression, acquisition of C1inh is vital to B. pertussis resistance to complement-mediated killing.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bordetella pertussis
/
Complement System Proteins
/
Complement C1 Inactivator Proteins
Limits:
Humans
Language:
En
Journal:
J Infect Dis
Year:
2007
Type:
Article
Affiliation country:
Canada