SAG protects human neuroblastoma SH-SY5Y cells against 1-methyl-4-phenylpyridinium ion (MPP+)-induced cytotoxicity via the downregulation of ROS generation and JNK signaling.

Kim, Sun-Yee; Kim, Mi-Yeon; Mo, Jung-Soon; Park, Jeen-Woo; Park, Hee-Sae

Kim, Sun-Yee; Kim, Mi-Yeon; Mo, Jung-Soon; Park, Jeen-Woo; Park, Hee-Sae.

Affiliation

Kim SY; Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Yongbong-dong, Buk-ku, Gwangju 500-757, Republic of Korea.

Neurosci Lett ; 413(2): 132-6, 2007 Feb 14.

Article in En | MEDLINE | ID: mdl-17240529

Subject(s)

1-Methyl-4-phenylpyridinium/toxicity; JNK Mitogen-Activated Protein Kinases/metabolism; Neurons/metabolism; Oxidative Stress/genetics; RNA-Binding Proteins/genetics; Reactive Oxygen Species/metabolism; Animals; Antioxidants/metabolism; Cell Line, Tumor; Cell Survival/drug effects; Cell Survival/genetics; Enzyme Activation/drug effects; Enzyme Activation/genetics; Gene Expression Regulation/genetics; Humans; MAP Kinase Kinase Kinase 1/metabolism; Mice; NIH 3T3 Cells; Neuroblastoma; Neurons/drug effects; Neurons/pathology; Neurotoxins/toxicity; Oxidative Stress/drug effects; Parkinson Disease/genetics; Parkinson Disease/physiopathology; Parkinson Disease/therapy; Ubiquitin-Protein Ligases

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Collection: 01-internacional Database: MEDLINE Main subject: 1-Methyl-4-phenylpyridinium / RNA-Binding Proteins / Reactive Oxygen Species / Oxidative Stress / JNK Mitogen-Activated Protein Kinases / Neurons Limits: Animals / Humans Language: En Journal: Neurosci Lett Year: 2007 Type: Article

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