Abortion due to Salmonella enterica serovar Abortusovis (S. Abortusovis) in ewes is associated to a lack of production of IFN-gamma and can be prevented by immunization with inactivated S. Abortusovis vaccine.
Vet Microbiol
; 121(3-4): 330-7, 2007 Apr 15.
Article
in En
| MEDLINE
| ID: mdl-17257785
ABSTRACT
Salmonellosis due to Salmonella enterica serovar Abortusovis (S. Abortusovis) is mainly characterized by abortion in sheep. Little is known about the immune response, which develops in the host as a result of infection. We evaluated the immune response of pregnant ewes vaccinated and successively exposed to full virulent S. Abortusovis. We found that vaccine constituted by inactivated S. Abortusovis induced both humoral and cellular-mediated immune response and that it provided protection against a challenge infection due to a fully virulent S. Abortusovis. Furthermore, we found an association between the lack of capability to produce IFN-gamma and abortion. This evidence suggests that protection against abortion can be associated to an IFN-gamma mediated mechanism. Our findings represent an interesting insight to better understand the interplay between host and S. Abortusovis and the effector mechanisms underpinning immune-based protection.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Salmonella Infections, Animal
/
Sheep Diseases
/
Interferon-gamma
/
Vaccination
/
Salmonella enterica
/
Abortion, Veterinary
/
Salmonella Vaccines
Type of study:
Risk_factors_studies
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Vet Microbiol
Year:
2007
Type:
Article
Affiliation country:
Italy