CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells.

LaRosa, David F; Gelman, Andrew E; Rahman, Adeeb H; Zhang, Jidong; Turka, Laurence A; Walsh, Patrick T

LaRosa, David F; Gelman, Andrew E; Rahman, Adeeb H; Zhang, Jidong; Turka, Laurence A; Walsh, Patrick T.

Affiliation

LaRosa DF; Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Immunol Lett ; 108(2): 183-8, 2007 Feb 15.

Article in En | MEDLINE | ID: mdl-17270282

Subject(s)

CD4-Positive T-Lymphocytes/drug effects; Lymphocyte Activation/immunology; Myeloid Differentiation Factor 88/physiology; Oligodeoxyribonucleotides/pharmacology; T-Lymphocytes, Regulatory/immunology; Adjuvants, Immunologic/pharmacology; Animals; Antigen-Presenting Cells/immunology; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/metabolism; Cell Proliferation/drug effects; Coculture Techniques; Forkhead Transcription Factors/metabolism; Immune Tolerance/drug effects; Immune Tolerance/immunology; Interleukin-2/metabolism; Interleukin-2/pharmacology; Interleukin-2 Receptor alpha Subunit/analysis; Lymphocyte Activation/drug effects; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88/deficiency; Myeloid Differentiation Factor 88/genetics; T-Lymphocytes, Regulatory/drug effects; T-Lymphocytes, Regulatory/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligodeoxyribonucleotides / Lymphocyte Activation / CD4-Positive T-Lymphocytes / T-Lymphocytes, Regulatory / Myeloid Differentiation Factor 88 Limits: Animals Language: En Journal: Immunol Lett Year: 2007 Type: Article Affiliation country: United States

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