Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample.
Eur J Hum Genet
; 15(4): 494-7, 2007 Apr.
Article
in En
| MEDLINE
| ID: mdl-17290274
ABSTRACT
Preeclampsia is a common, pregnancy-specific vascular disorder characterised by hypertension and proteinuria. A recent report suggested association of the STOX1 gene on chromosome 10q22.1 with preeclampsia in the Dutch population. Here, we present a comprehensive assessment of STOX1 as a candidate gene for preeclampsia in the Finnish population by re-examining our previous genetic linkage analysis results for both chromosome 10 and paralogous loci, by genotyping representative markers in a nationwide data set, and by studying STOX1 expression in placentas from preeclamptic and uncomplicated pregnancies. In conclusion, we are unable to validate STOX1 as a common preeclampsia susceptibility gene.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pre-Eclampsia
/
Genetic Variation
/
Haplotypes
/
Carrier Proteins
/
Genetic Testing
/
Population Groups
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Evaluation_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
/
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Europa
Language:
En
Journal:
Eur J Hum Genet
Journal subject:
GENETICA MEDICA
Year:
2007
Type:
Article
Affiliation country:
Sweden