Optimizing the development of targeted agents in pancreatic cancer: tumor fine-needle aspiration biopsy as a platform for novel prospective ex vivo drug sensitivity assays.

Rubio-Viqueira, Belen; Mezzadra, Heather; Nielsen, Matthew E; Jimeno, Antonio; Zhang, Xianfeng; Iacobuzio-Donahue, Christine; Maitra, Anirban; Hidalgo, Manuel; Altiok, Soner

Rubio-Viqueira, Belen; Mezzadra, Heather; Nielsen, Matthew E; Jimeno, Antonio; Zhang, Xianfeng; Iacobuzio-Donahue, Christine; Maitra, Anirban; Hidalgo, Manuel; Altiok, Soner.

Affiliation

Rubio-Viqueira B; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.

Mol Cancer Ther ; 6(2): 515-23, 2007 Feb.

Article in En | MEDLINE | ID: mdl-17308050

Subject(s)

Drug Resistance, Neoplasm; Pancreatic Neoplasms/drug therapy; Protein Kinase Inhibitors/therapeutic use; Quinazolines/therapeutic use; Sirolimus/analogs & derivatives; Xenograft Model Antitumor Assays; Adenocarcinoma/drug therapy; Animals; Biopsy, Fine-Needle; ErbB Receptors/antagonists & inhibitors; Erlotinib Hydrochloride; Humans; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/antagonists & inhibitors; Mitogen-Activated Protein Kinase 3/metabolism; Prospective Studies; Sirolimus/therapeutic use

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Quinazolines / Drug Resistance, Neoplasm / Sirolimus / Xenograft Model Antitumor Assays / Protein Kinase Inhibitors Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2007 Type: Article Affiliation country: United States

Search on Google

XML

PubMed Links