Antidonor antibody in patients receiving ABO-identical and HLA-mismatched living donor liver transplants: effect on survival.
Transplantation
; 83(4): 506-9, 2007 Feb 27.
Article
in En
| MEDLINE
| ID: mdl-17318084
ABSTRACT
We retrospectively determined the correlation of results of lymphocyte crossmatch tests by direct complement-dependent cytotoxicity, to the outcomes of 585 consecutive ABO-identical and human leukocyte antigen (HLA)-mismatched living donor liver transplants (LDLTs) (malefemale=276309; median age, 18 years). Crossmatch test results were positive in 14 recipients (2.4%). Patient survival at eight years in the crossmatch-positive group was significantly lower than in the crossmatch-negative group (positive group, 56.3%; negative group, 77.6%; P=0.014). The survival at five years of the crossmatch-positive group was significantly lower than the negative group in both older recipients (>or=18 years of age positive group, 41.7%; negative group, 76.4%; P=0.0065), and female recipients (positive group, 37.5%; negative group, 81.9%; P=3.3x10). We conclude that antidonor antibodies have adverse effects on the clinical outcome of LDLTs, and that being female and/or older aged (>or=18 years of age) are risk factors for LDLT.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
ABO Blood-Group System
/
Liver Transplantation
/
Living Donors
/
HLA Antigens
/
Antibodies
Type of study:
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Middle aged
Language:
En
Journal:
Transplantation
Year:
2007
Type:
Article
Affiliation country:
Japan