Identification, synthesis, and biological evaluation of novel pyrazoles as low molecular weight luteinizing hormone receptor agonists.

Jorand-Lebrun, Catherine; Brondyk, Bill; Lin, Jing; Magar, Sharad; Murray, Robert; Reddy, Adulla; Shroff, Hitesh; Wands, Greg; Weiser, Weishui; Xu, Qihong; McKenna, Sean; Brugger, Nadia

Jorand-Lebrun, Catherine; Brondyk, Bill; Lin, Jing; Magar, Sharad; Murray, Robert; Reddy, Adulla; Shroff, Hitesh; Wands, Greg; Weiser, Weishui; Xu, Qihong; McKenna, Sean; Brugger, Nadia.

Affiliation

Jorand-Lebrun C; Merck Serono Geneva Research Center, Bat. B3, 9, chemin des Mines, 1211 Geneva, Switzerland. catherine.jorandlebrun@merckserono.net

Bioorg Med Chem Lett ; 17(7): 2080-5, 2007 Apr 01.

Article in En | MEDLINE | ID: mdl-17321742

Subject(s)

Chemistry, Pharmaceutical/methods; Pyrazoles/chemical synthesis; Pyrazoles/pharmacology; Receptors, LH/agonists; Animals; CHO Cells; Cricetinae; Cricetulus; Drug Design; Leydig Cells/metabolism; Male; Molecular Conformation; Molecular Weight; Rats; Structure-Activity Relationship; Testosterone/chemistry; Testosterone/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Receptors, LH / Chemistry, Pharmaceutical Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2007 Type: Article Affiliation country: Switzerland

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