Population pharmacokinetic analysis of the new oral thrombin inhibitor dabigatran etexilate (BIBR 1048) in patients undergoing primary elective total hip replacement surgery.

Trocóniz, Iñaki F; Tillmann, Christiane; Liesenfeld, Karl-Heinz; Schäfer, Hans-Günter; Stangier, Joachim

Trocóniz, Iñaki F; Tillmann, Christiane; Liesenfeld, Karl-Heinz; Schäfer, Hans-Günter; Stangier, Joachim.

Affiliation

Trocóniz IF; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 68, 88397 Biberach, Germany.

J Clin Pharmacol ; 47(3): 371-82, 2007 Mar.

Article in En | MEDLINE | ID: mdl-17322149

Subject(s)

Arthroplasty, Replacement, Hip/methods; Benzimidazoles/pharmacokinetics; Postoperative Complications/prevention & control; Pyridines/pharmacokinetics; Venous Thrombosis/prevention & control; Administration, Oral; Aged; Algorithms; Anticoagulants/administration & dosage; Anticoagulants/blood; Anticoagulants/pharmacokinetics; Benzimidazoles/administration & dosage; Benzimidazoles/blood; Chromatography, Liquid; Dabigatran; Dose-Response Relationship, Drug; Drug Administration Schedule; Elective Surgical Procedures/methods; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Pyridines/administration & dosage; Pyridines/blood; Software; Tablets; Tandem Mass Spectrometry

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Collection: 01-internacional Database: MEDLINE Main subject: Postoperative Complications / Pyridines / Benzimidazoles / Arthroplasty, Replacement, Hip / Venous Thrombosis Type of study: Clinical_trials / Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: J Clin Pharmacol Year: 2007 Type: Article Affiliation country: Germany

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