Improved pharmacokinetics of recombinant bispecific antibody molecules by fusion to human serum albumin.

Müller, Dafne; Karle, Anette; Meissburger, Bettina; Höfig, Ines; Stork, Roland; Kontermann, Roland E

Müller, Dafne; Karle, Anette; Meissburger, Bettina; Höfig, Ines; Stork, Roland; Kontermann, Roland E.

Affiliation

Müller D; Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.

J Biol Chem ; 282(17): 12650-60, 2007 Apr 27.

Article in En | MEDLINE | ID: mdl-17347147

Subject(s)

Antibodies, Bispecific/pharmacokinetics; CD3 Complex/immunology; Carcinoembryonic Antigen/immunology; Serum Albumin/pharmacokinetics; Animals; Antibodies, Bispecific/genetics; Antibodies, Bispecific/immunology; Antibodies, Bispecific/pharmacology; Drug Screening Assays, Antitumor; Humans; Immunity, Cellular/drug effects; Mice; Neoplasms/drug therapy; Neoplasms/immunology; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/immunology; Recombinant Fusion Proteins/pharmacokinetics; Recombinant Fusion Proteins/pharmacology; Serum Albumin/genetics; Serum Albumin/immunology; Serum Albumin/pharmacology; T-Lymphocytes/immunology

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Serum Albumin / Carcinoembryonic Antigen / CD3 Complex / Antibodies, Bispecific Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2007 Type: Article Affiliation country: Germany

Search on Google

XML

PubMed Links