4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships.

Frølund, Bente; Jensen, Lars S; Storustovu, Signe I; Stensbøl, Tine B; Ebert, Bjarke; Kehler, Jan; Krogsgaard-Larsen, Povl; Liljefors, Tommy

Frølund, Bente; Jensen, Lars S; Storustovu, Signe I; Stensbøl, Tine B; Ebert, Bjarke; Kehler, Jan; Krogsgaard-Larsen, Povl; Liljefors, Tommy.

Affiliation

Frølund B; Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark. bfr@farma.ku.dk

J Med Chem ; 50(8): 1988-92, 2007 Apr 19.

Article in En | MEDLINE | ID: mdl-17375905

Subject(s)

GABA-A Receptor Antagonists; Isoxazoles/chemical synthesis; Piperidines/chemical synthesis; Pyridazines/chemical synthesis; Animals; Female; Humans; In Vitro Techniques; Isoxazoles/chemistry; Isoxazoles/pharmacology; Models, Molecular; Molecular Conformation; Oocytes/drug effects; Oocytes/physiology; Patch-Clamp Techniques; Piperidines/chemistry; Piperidines/pharmacology; Pyridazines/chemistry; Pyridazines/pharmacology; Structure-Activity Relationship; Xenopus

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Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Pyridazines / GABA-A Receptor Antagonists / Isoxazoles Limits: Animals / Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Type: Article Affiliation country: Denmark

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