Recent developments in nitric oxide donor drugs.
Br J Pharmacol
; 151(3): 305-21, 2007 Jun.
Article
in En
| MEDLINE
| ID: mdl-17401442
ABSTRACT
During the 1980s, the free radical, nitric oxide (NO), was discovered to be a crucial signalling molecule, with wide-ranging functions in the cardiovascular, nervous and immune systems. Aside from providing a credible explanation for the actions of organic nitrates and sodium nitroprusside that have long been used in the treatment of angina and hypertensive crises respectively, the discovery generated great hopes for new NO-based treatments for a wide variety of ailments. Decades later, however, we are still awaiting novel licensed agents in this arena, despite an enormous research effort to this end. This review explores some of the most promising recent advances in NO donor drug development and addresses the challenges associated with NO as a therapeutic agent.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiovascular Physiological Phenomena
/
Nitric Oxide Donors
Limits:
Animals
/
Humans
Language:
En
Journal:
Br J Pharmacol
Year:
2007
Type:
Article
Affiliation country:
United kingdom