Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.

Pollard, Patrick J; Spencer-Dene, Bradley; Shukla, Deepa; Howarth, Kimberley; Nye, Emma; El-Bahrawy, Mona; Deheragoda, Maesha; Joannou, Maria; McDonald, Stuart; Martin, Alison; Igarashi, Peter; Varsani-Brown, Sunita; Rosewell, Ian; Poulsom, Richard; Maxwell, Patrick; Stamp, Gordon W; Tomlinson, Ian P M

Pollard, Patrick J; Spencer-Dene, Bradley; Shukla, Deepa; Howarth, Kimberley; Nye, Emma; El-Bahrawy, Mona; Deheragoda, Maesha; Joannou, Maria; McDonald, Stuart; Martin, Alison; Igarashi, Peter; Varsani-Brown, Sunita; Rosewell, Ian; Poulsom, Richard; Maxwell, Patrick; Stamp, Gordon W; Tomlinson, Ian P M.

Affiliation

Pollard PJ; Molecular and Population Genetics Laboratory, Histopathology Department, London Research Institute, Cancer Research UK, Hammersmith Hospital, Imperial College London, United Kingdom. patrick.pollard@cancer.org.uk

Cancer Cell ; 11(4): 311-9, 2007 Apr.

Article in En | MEDLINE | ID: mdl-17418408

Subject(s)

Carcinoma, Renal Cell/etiology; Fumarate Hydratase/genetics; Gene Silencing/physiology; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Kidney Diseases, Cystic/etiology; Kidney Neoplasms/etiology; Animals; Basic Helix-Loop-Helix Transcription Factors/metabolism; Carcinoma, Renal Cell/metabolism; Carcinoma, Renal Cell/pathology; Cell Hypoxia; Cell Proliferation; Female; Glucose Transporter Type 1/metabolism; Kidney Diseases, Cystic/metabolism; Kidney Diseases, Cystic/pathology; Kidney Neoplasms/metabolism; Kidney Neoplasms/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Signal Transduction; Vascular Endothelial Growth Factor A/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Renal Cell / Gene Silencing / Kidney Diseases, Cystic / Hypoxia-Inducible Factor 1, alpha Subunit / Fumarate Hydratase / Kidney Neoplasms Type of study: Etiology_studies Limits: Animals Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2007 Type: Article Affiliation country: United kingdom

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