Your browser doesn't support javascript.
loading
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia.
Lahortiga, Idoya; De Keersmaecker, Kim; Van Vlierberghe, Pieter; Graux, Carlos; Cauwelier, Barbara; Lambert, Frederic; Mentens, Nicole; Beverloo, H Berna; Pieters, Rob; Speleman, Frank; Odero, Maria D; Bauters, Marijke; Froyen, Guy; Marynen, Peter; Vandenberghe, Peter; Wlodarska, Iwona; Meijerink, Jules P P; Cools, Jan.
Affiliation
  • Lahortiga I; Human Genome Laboratory, Department of Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium.
Nat Genet ; 39(5): 593-5, 2007 May.
Article in En | MEDLINE | ID: mdl-17435759
We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.
Subject(s)
Search on Google
Print
XML
PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Leukemia-Lymphoma, Adult T-Cell / Cell Differentiation / Gene Duplication / Genes, myb Limits: Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2007 Type: Article Affiliation country: Belgium
Search on Google
Print
XML
PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Leukemia-Lymphoma, Adult T-Cell / Cell Differentiation / Gene Duplication / Genes, myb Limits: Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2007 Type: Article Affiliation country: Belgium