Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes.

Wanrooij, Sjoerd; Goffart, Steffi; Pohjoismäki, Jaakko L O; Yasukawa, Takehiro; Spelbrink, Johannes N

Wanrooij, Sjoerd; Goffart, Steffi; Pohjoismäki, Jaakko L O; Yasukawa, Takehiro; Spelbrink, Johannes N.

Affiliation

Wanrooij S; Institute of Medical Technology and Tampere University Hospital, Tampere, Finland.

Nucleic Acids Res ; 35(10): 3238-51, 2007.

Article in En | MEDLINE | ID: mdl-17452351

Subject(s)

DNA Helicases/physiology; DNA Replication; DNA, Mitochondrial/biosynthesis; DNA-Directed DNA Polymerase/physiology; Catalytic Domain; Cell Line; DNA Helicases/genetics; DNA Helicases/metabolism; DNA Polymerase gamma; DNA-Directed DNA Polymerase/genetics; DNA-Directed DNA Polymerase/metabolism; Electrophoresis, Gel, Two-Dimensional; Humans; Mitochondrial Proteins; Mutation; Phenotype

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA, Mitochondrial / DNA Helicases / DNA-Directed DNA Polymerase / DNA Replication Type of study: Etiology_studies Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2007 Type: Article Affiliation country: Finland

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