Temozolomide and thalidomide in the treatment of glioblastoma multiforme.
Anticancer Res
; 27(2): 1067-71, 2007.
Article
in En
| MEDLINE
| ID: mdl-17465245
ABSTRACT
OBJECTIVE:
The aim of this study was to assess efficacy and toxicity of temozolomide given alone or in combination with thalidomide, an anti-angiogenetic drug, in patients with newly diagnosed glioblastoma multiforme (GBM). PATIENTS ANDMETHODS:
46 patients with histologically proven GBM were eligible for inclusion. Twenty-three patients (15 males and 8 females) received temozolomide on a conventional schedule; 23 patients (12 males and 11 females) received temozolomide on the same schedule and thalidomide was dose-adjusted in each individual patient based on their tolerance.RESULTS:
The median survival time was 12 months for temozolomide and 13 months for temozolomide + thalidomide.CONCLUSION:
The administration of temozolomide in association with thalidomide after radiotherapy (RT) does not offer an advantage over temozolomide alone in adults with newly diagnosed GBM. The two therapeutic strategies produce similar results for survival, but the latter regimen shows a moderate increase in toxicity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Antineoplastic Combined Chemotherapy Protocols
/
Glioblastoma
/
Dacarbazine
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Anticancer Res
Year:
2007
Type:
Article
Affiliation country:
Italy