Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes.

Calderari, S; Gangnerau, M-N; Thibault, M; Meile, M-J; Kassis, N; Alvarez, C; Portha, B; Serradas, P

Calderari, S; Gangnerau, M-N; Thibault, M; Meile, M-J; Kassis, N; Alvarez, C; Portha, B; Serradas, P.

Affiliation

Calderari S; Laboratory of Physiopathology of Nutrition, UMR CNRS 7059, University of Paris 7, 2 place Jussieu, 75251, Paris Cedex 05, France. sophie.calderari@college-de-france.fr

Diabetologia ; 50(7): 1463-71, 2007 Jul.

Article in En | MEDLINE | ID: mdl-17476475

Subject(s)

Diabetes Mellitus, Type 2/genetics; Gene Expression Regulation, Developmental; Insulin-Like Growth Factor II/physiology; Insulin-Secreting Cells/metabolism; Pancreas/embryology; Receptor, IGF Type 1/physiology; Animals; Blood Glucose/metabolism; Cell Differentiation; Diabetes Mellitus, Type 2/metabolism; Female; Humans; Insulin-Like Growth Factor II/genetics; Insulin-Secreting Cells/cytology; Mice; NIH 3T3 Cells; Pancreas/abnormalities; Rats; Rats, Wistar; Receptor, IGF Type 1/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Pancreas / Insulin-Like Growth Factor II / Receptor, IGF Type 1 / Gene Expression Regulation, Developmental / Diabetes Mellitus, Type 2 / Insulin-Secreting Cells Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Diabetologia Year: 2007 Type: Article Affiliation country: France

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