The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes.

Yoshikawa, Yoko; Satoh, Takaya; Tamura, Takashi; Wei, Ping; Bilasy, Shymaa E; Edamatsu, Hironori; Aiba, Atsu; Katagiri, Koko; Kinashi, Tatsuo; Nakao, Kazuki; Kataoka, Tohru

Yoshikawa, Yoko; Satoh, Takaya; Tamura, Takashi; Wei, Ping; Bilasy, Shymaa E; Edamatsu, Hironori; Aiba, Atsu; Katagiri, Koko; Kinashi, Tatsuo; Nakao, Kazuki; Kataoka, Tohru.

Affiliation

Yoshikawa Y; Division of Molecular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.

Mol Biol Cell ; 18(8): 2949-59, 2007 Aug.

Article in En | MEDLINE | ID: mdl-17538012

Subject(s)

Guanine Nucleotide Exchange Factors/metabolism; Integrins/metabolism; Monomeric GTP-Binding Proteins/metabolism; Spleen/cytology; Tumor Necrosis Factor-alpha/pharmacology; rap1 GTP-Binding Proteins/metabolism; ras Proteins/metabolism; Animals; Cell Adhesion/drug effects; Cell Aggregation/drug effects; Enzyme Activation/drug effects; Gene Targeting; Humans; Intercellular Adhesion Molecule-1/metabolism; Lymphocyte Function-Associated Antigen-1/metabolism; Mice; Models, Biological; Spleen/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spleen / Integrins / Tumor Necrosis Factor-alpha / Ras Proteins / Monomeric GTP-Binding Proteins / Rap1 GTP-Binding Proteins / Guanine Nucleotide Exchange Factors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Biol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2007 Type: Article Affiliation country: Japan

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