The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor.

Wen, Xiaoyun; Duus, Karen M; Friedrich, Thomas D; de Noronha, Carlos M C

Wen, Xiaoyun; Duus, Karen M; Friedrich, Thomas D; de Noronha, Carlos M C.

Affiliation

Wen X; Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208.
Duus KM; Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208.
Friedrich TD; Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208.
de Noronha CMC; Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208. Electronic address: DeNoroC@mail.AMC.edu.

J Biol Chem ; 282(37): 27046-27057, 2007 Sep 14.

Article in En | MEDLINE | ID: mdl-17620334

Subject(s)

Carrier Proteins/physiology; Cullin Proteins/physiology; DNA-Binding Proteins/physiology; G2 Phase; Gene Products, vpr/physiology; Ubiquitin-Protein Ligases/physiology; Cells, Cultured; Humans; Immunoprecipitation; Uracil-DNA Glycosidase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carrier Proteins / G2 Phase / Gene Products, vpr / Ubiquitin-Protein Ligases / Cullin Proteins / DNA-Binding Proteins Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2007 Type: Article

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