Quinone oxidoreductase (NQO1) gene polymorphism may not confer a susceptibility to mood disorders.

Pae, Chi-Un; Yoon, Soo-Jung; Patkar, Ashwin A; Kim, Jung-Jin; Lee, Chul; Paik, In-Ho

Pae, Chi-Un; Yoon, Soo-Jung; Patkar, Ashwin A; Kim, Jung-Jin; Lee, Chul; Paik, In-Ho.

Affiliation

Pae CU; Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, 505 Banpo-Dong, Seocho-Gu, Seoul 137-701, South Korea. pae@catholic.ac.kr

Psychiatry Res ; 153(1): 83-6, 2007 Sep 30.

Article in En | MEDLINE | ID: mdl-17644186

ABSTRACT

ABSTRACT

Quinone oxidoreductase (NQO1) plays a key role in the cellular antioxidant defense by detoxifying quinine derivatives. Case-control association study of the possible relationship between the NQO1 gene polymorphism and mood disorders (patients with major depressive disorder, n=61; patients with bipolar I disorder, n=80; control, n=106) was carried out using PCR-based techniques. These preliminary results showed that the NQO1 gene polymorphism was not related to a susceptibility to mood disorders.

Subject(s)

Bipolar Disorder/genetics; Depressive Disorder, Major/genetics; Genetic Predisposition to Disease/genetics; NAD(P)H Dehydrogenase (Quinone)/genetics; Polymorphism, Genetic/genetics; Adult; Bipolar Disorder/diagnosis; Bipolar Disorder/psychology; Depressive Disorder, Major/diagnosis; Depressive Disorder, Major/psychology; Female; Genotype; Humans; Korea; Male; Middle Aged

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Collection: 01-internacional Database: MEDLINE Main subject: Polymorphism, Genetic / Bipolar Disorder / NAD(P)H Dehydrogenase (Quinone) / Genetic Predisposition to Disease / Depressive Disorder, Major Type of study: Diagnostic_studies Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Psychiatry Res Year: 2007 Type: Article Affiliation country: South Korea

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