Rate-limiting steps and role of active site Lys443 in the mechanism of carbapenam synthetase.

Arnett, Samantha O; Gerratana, Barbara; Townsend, Craig A

Arnett, Samantha O; Gerratana, Barbara; Townsend, Craig A.

Affiliation

Arnett SO; Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.

Biochemistry ; 46(32): 9337-45, 2007 Aug 14.

Article in En | MEDLINE | ID: mdl-17658887

Subject(s)

Carbon-Nitrogen Ligases/chemistry; Carbon-Nitrogen Ligases/metabolism; Lysine/chemistry; Lysine/physiology; Alanine/genetics; Binding Sites; Carbon-Nitrogen Ligases/genetics; Carbon-Nitrogen Ligases/isolation & purification; Catalysis; Deuterium/chemistry; Enzyme Activation/genetics; Escherichia coli Proteins/chemistry; Escherichia coli Proteins/genetics; Escherichia coli Proteins/isolation & purification; Escherichia coli Proteins/metabolism; Genetic Variation; Hydrogen-Ion Concentration; Kinetics; Lysine/genetics; Solvents/chemistry; Substrate Specificity/genetics; Viscosity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbon-Nitrogen Ligases / Lysine Language: En Journal: Biochemistry Year: 2007 Type: Article Affiliation country: United States

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