Soluble guanylate cyclase-alpha1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia.

Vermeersch, Pieter; Buys, Emmanuel; Pokreisz, Peter; Marsboom, Glenn; Ichinose, Fumito; Sips, Patrick; Pellens, Marijke; Gillijns, Hilde; Swinnen, Marc; Graveline, Amanda; Collen, Desire; Dewerchin, Mieke; Brouckaert, Peter; Bloch, Kenneth D; Janssens, Stefan

Vermeersch, Pieter; Buys, Emmanuel; Pokreisz, Peter; Marsboom, Glenn; Ichinose, Fumito; Sips, Patrick; Pellens, Marijke; Gillijns, Hilde; Swinnen, Marc; Graveline, Amanda; Collen, Desire; Dewerchin, Mieke; Brouckaert, Peter; Bloch, Kenneth D; Janssens, Stefan.

Affiliation

Vermeersch P; Center for Transgene Technology and Gene Therapy, VIB, Leuven, Belgium.

Circulation ; 116(8): 936-43, 2007 Aug 21.

Article in En | MEDLINE | ID: mdl-17679618

Subject(s)

Guanylate Cyclase/genetics; Guanylate Cyclase/metabolism; Hypertension, Pulmonary/physiopathology; Hypoxia/physiopathology; Nitric Oxide/metabolism; Receptors, Cytoplasmic and Nuclear/genetics; Receptors, Cytoplasmic and Nuclear/metabolism; Vasodilation/physiology; Acute Disease; Animals; Antimetabolites/pharmacokinetics; Blood Pressure/physiology; Bromodeoxyuridine/pharmacokinetics; Chronic Disease; Cyclic GMP/metabolism; Dimerization; Female; Guanylate Cyclase/chemistry; Hypertension, Pulmonary/metabolism; Hypertrophy, Right Ventricular/metabolism; Hypertrophy, Right Ventricular/physiopathology; Hypoxia/metabolism; Male; Mice; Mice, Mutant Strains; Pulmonary Artery/physiology; Pulmonary Circulation/physiology; Receptors, Cytoplasmic and Nuclear/chemistry; Soluble Guanylyl Cyclase; Ventricular Function, Right/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Vasodilation / Receptors, Cytoplasmic and Nuclear / Guanylate Cyclase / Hypertension, Pulmonary / Hypoxia / Nitric Oxide Limits: Animals Language: En Journal: Circulation Year: 2007 Type: Article Affiliation country: Belgium

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