Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury.

Doyle, Kristian P; Suchland, Katherine L; Ciesielski, Thomas M P; Lessov, Nikola S; Grandy, David K; Scanlan, Thomas S; Stenzel-Poore, Mary P

Doyle, Kristian P; Suchland, Katherine L; Ciesielski, Thomas M P; Lessov, Nikola S; Grandy, David K; Scanlan, Thomas S; Stenzel-Poore, Mary P.

Affiliation

Doyle KP; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA.

Stroke ; 38(9): 2569-76, 2007 Sep.

Article in En | MEDLINE | ID: mdl-17690312

Subject(s)

Hypothermia/chemically induced; Neuroprotective Agents; Stroke/pathology; Thyronines; Thyroxine/analogs & derivatives; Animals; Behavior, Animal/physiology; Body Temperature; Brain Ischemia/pathology; Cells, Cultured; Humans; Ischemic Preconditioning; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Neurons/cytology; Neurons/metabolism; Neuroprotective Agents/chemistry; Neuroprotective Agents/metabolism; Neuroprotective Agents/pharmacology; Stroke/prevention & control; Thyronines/chemistry; Thyronines/metabolism; Thyronines/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Thyronines / Thyroxine / Neuroprotective Agents / Stroke / Hypothermia Limits: Animals / Humans / Male Language: En Journal: Stroke Year: 2007 Type: Article Affiliation country: United States

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