New light on an old story: facile and efficient synthesis of 1,3-diaryl-5-spirohexahydropyrimidines via a six-molecule, three-component mannich-type reaction.
J Org Chem
; 72(22): 8600-3, 2007 Oct 26.
Article
in En
| MEDLINE
| ID: mdl-17918899
ABSTRACT
A facile and efficient synthesis of 1,3-diaryl-5-spirohexahydropyrimidines via a one-pot condensation of anilines, formaldehyde, and cyclohexanones is reported. In this one-pot, three-component reaction, six molecules of reactants are involved and six new covalent bonds are generated. Bicyclic products are obtained from the starting materials in one pot using readily available starting materials and catalysts.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyridines
/
Pyrimidines
/
Cyclohexanones
/
Formaldehyde
Language:
En
Journal:
J Org Chem
Year:
2007
Type:
Article