Deacetylase inhibition promotes the generation and function of regulatory T cells.

Tao, Ran; de Zoeten, Edwin F; Ozkaynak, Engin; Chen, Chunxia; Wang, Liqing; Porrett, Paige M; Li, Bin; Turka, Laurence A; Olson, Eric N; Greene, Mark I; Wells, Andrew D; Hancock, Wayne W

Tao, Ran; de Zoeten, Edwin F; Ozkaynak, Engin; Chen, Chunxia; Wang, Liqing; Porrett, Paige M; Li, Bin; Turka, Laurence A; Olson, Eric N; Greene, Mark I; Wells, Andrew D; Hancock, Wayne W.

Affiliation

Tao R; Division of Transplantation Immunology, Department of Pathology and Laboratory Medicine and Biesecker Center for Studies of Pediatric Liver Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4318, USA.

Nat Med ; 13(11): 1299-307, 2007 Nov.

Article in En | MEDLINE | ID: mdl-17922010

Subject(s)

Cell Differentiation/immunology; Histone Deacetylase Inhibitors; Lymphocyte Activation/immunology; T-Lymphocytes, Regulatory/cytology; T-Lymphocytes, Regulatory/enzymology; Animals; Forkhead Transcription Factors/biosynthesis; Histone Deacetylases/biosynthesis; Histone Deacetylases/genetics; Hydroxamic Acids/pharmacology; Lymphocyte Activation/drug effects; Mice; Mice, Congenic; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Mice, SCID; Mice, Transgenic; T-Lymphocytes, Regulatory/immunology; Thymus Gland/cytology; Thymus Gland/immunology; Thymus Gland/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Lymphocyte Activation / Cell Differentiation / T-Lymphocytes, Regulatory / Histone Deacetylase Inhibitors Limits: Animals Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2007 Type: Article Affiliation country: United States

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