Discovery of dibenzo[c,f][2,7]naphthyridines as potent and selective 3-phosphoinositide-dependent kinase-1 inhibitors.

Gopalsamy, Ariamala; Shi, Mengxiao; Boschelli, Diane H; Williamson, Robert; Olland, Andrea; Hu, Yongbo; Krishnamurthy, Girija; Han, Xin; Arndt, Kim; Guo, Bing

Gopalsamy, Ariamala; Shi, Mengxiao; Boschelli, Diane H; Williamson, Robert; Olland, Andrea; Hu, Yongbo; Krishnamurthy, Girija; Han, Xin; Arndt, Kim; Guo, Bing.

Affiliation

Gopalsamy A; Chemical and Screening Sciences and Oncology, Wyeth Research, 401 N. Middletown Road, Pearl River, NY 10965, USA. gopalsa@wyeth.com

J Med Chem ; 50(23): 5547-9, 2007 Nov 15.

Article in En | MEDLINE | ID: mdl-17941624

Subject(s)

Naphthyridines/chemical synthesis; Protein Serine-Threonine Kinases/antagonists & inhibitors; 3-Phosphoinositide-Dependent Protein Kinases; Binding Sites; Crystallography, X-Ray; Models, Molecular; Molecular Structure; Naphthyridines/chemistry; Protein Serine-Threonine Kinases/chemistry; Structure-Activity Relationship

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Protein Serine-Threonine Kinases / Naphthyridines Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Type: Article Affiliation country: United States

Search on Google

XML

PubMed Links