Neural substrates of awakening probed with optogenetic control of hypocretin neurons.

Adamantidis, Antoine R; Zhang, Feng; Aravanis, Alexander M; Deisseroth, Karl; de Lecea, Luis

Adamantidis, Antoine R; Zhang, Feng; Aravanis, Alexander M; Deisseroth, Karl; de Lecea, Luis.

Affiliation

Adamantidis AR; Department of Psychiatry and Behavioral Sciences, Stanford University, 701B Welch Road, Palo Alto, California 94304, USA.

Nature ; 450(7168): 420-4, 2007 Nov 15.

Article in En | MEDLINE | ID: mdl-17943086

Subject(s)

Intracellular Signaling Peptides and Proteins/metabolism; Neurons/metabolism; Neurons/radiation effects; Neuropeptides/metabolism; Sleep/physiology; Wakefulness/physiology; Animals; Circadian Rhythm/radiation effects; Hypothalamus/cytology; Hypothalamus/metabolism; Intracellular Signaling Peptides and Proteins/deficiency; Intracellular Signaling Peptides and Proteins/genetics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuropeptides/deficiency; Neuropeptides/genetics; Orexin Receptors; Orexins; Patch-Clamp Techniques; Receptors, G-Protein-Coupled/antagonists & inhibitors; Receptors, G-Protein-Coupled/metabolism; Receptors, Neuropeptide/antagonists & inhibitors; Receptors, Neuropeptide/metabolism; Rhodopsin/genetics; Rhodopsin/metabolism; Sleep/genetics; Sleep/radiation effects; Sleep, REM/physiology; Sleep, REM/radiation effects; Wakefulness/genetics; Wakefulness/radiation effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sleep / Wakefulness / Neuropeptides / Intracellular Signaling Peptides and Proteins / Neurons Limits: Animals Language: En Journal: Nature Year: 2007 Type: Article Affiliation country: United States

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