Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors.
J Med Chem
; 50(24): 5882-5, 2007 Nov 29.
Article
in En
| MEDLINE
| ID: mdl-17963373
ABSTRACT
A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat P2X7 receptor and provides useful pharmacological tools for evaluation of the role of P2X7 in disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzamides
/
Adamantane
/
Interleukin-1beta
/
Purinergic P2 Receptor Antagonists
Limits:
Animals
/
Humans
Language:
En
Journal:
J Med Chem
Journal subject:
QUIMICA
Year:
2007
Type:
Article
Affiliation country:
United kingdom