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Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors.
Furber, Mark; Alcaraz, Lilian; Bent, Janice E; Beyerbach, Armin; Bowers, Keith; Braddock, Martin; Caffrey, Moya V; Cladingboel, David; Collington, John; Donald, David K; Fagura, Malbinder; Ince, Frank; Kinchin, Elizabeth C; Laurent, Celine; Lawson, Mandy; Luker, Timothy J; Mortimore, Michael M P; Pimm, Austen D; Riley, Robert J; Roberts, Nicola; Robertson, Mark; Theaker, Jill; Thorne, Philip V; Weaver, Richard; Webborn, Peter; Willis, Paul.
Affiliation
  • Furber M; Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leics, U.K. mark1.furber@astrazeneca.com
J Med Chem ; 50(24): 5882-5, 2007 Nov 29.
Article in En | MEDLINE | ID: mdl-17963373
ABSTRACT
A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat P2X7 receptor and provides useful pharmacological tools for evaluation of the role of P2X7 in disease.
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Collection: 01-internacional Database: MEDLINE Main subject: Benzamides / Adamantane / Interleukin-1beta / Purinergic P2 Receptor Antagonists Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Type: Article Affiliation country: United kingdom
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Collection: 01-internacional Database: MEDLINE Main subject: Benzamides / Adamantane / Interleukin-1beta / Purinergic P2 Receptor Antagonists Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Type: Article Affiliation country: United kingdom