Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor.

Batenburg, Wendy W; Krop, Manne; Garrelds, Ingrid M; de Vries, René; de Bruin, René J A; Burcklé, Celine A; Müller, Dominik N; Bader, Michael; Nguyen, Geneviève; Danser, A H Jan

Batenburg, Wendy W; Krop, Manne; Garrelds, Ingrid M; de Vries, René; de Bruin, René J A; Burcklé, Celine A; Müller, Dominik N; Bader, Michael; Nguyen, Geneviève; Danser, A H Jan.

Affiliation

Batenburg WW; Erasmus MC, Rotterdam, The Netherlands.

J Hypertens ; 25(12): 2441-53, 2007 Dec.

Article in En | MEDLINE | ID: mdl-17984666

Subject(s)

Muscle, Smooth, Vascular/metabolism; Receptors, Cell Surface/metabolism; Renin/metabolism; Angiotensinogen/metabolism; Angiotensinogen/pharmacology; Angiotensins/biosynthesis; Animals; Animals, Genetically Modified; Cells, Cultured; Humans; Iliac Artery/drug effects; Iliac Artery/physiology; In Vitro Techniques; Kinetics; Protein Precursors/metabolism; Protein Precursors/pharmacology; Rats; Receptor, IGF Type 2/antagonists & inhibitors; Receptor, IGF Type 2/metabolism; Receptors, Cell Surface/agonists; Receptors, Cell Surface/genetics; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Renin/pharmacology; Vasoconstriction/drug effects; Vasoconstriction/physiology; Prorenin Receptor

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Collection: 01-internacional Database: MEDLINE Main subject: Renin / Receptors, Cell Surface / Muscle, Smooth, Vascular Limits: Animals / Humans Language: En Journal: J Hypertens Year: 2007 Type: Article Affiliation country: Netherlands

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