Prenatal vitamin A deficiency causes laryngeal malformation in rats.
Ann Otol Rhinol Laryngol
; 116(10): 785-92, 2007 Oct.
Article
in En
| MEDLINE
| ID: mdl-17987785
ABSTRACT
OBJECTIVES:
Our previous research demonstrated that vitamin A might be related to vocal fold development. The purpose of this study was to determine whether vitamin A deficiency affects prenatal laryngeal development in rats.METHODS:
Two considerations were necessary in designing a study using a rat model for embryonic survival, vitamin A is necessary through day 10 of gestation, and laryngeal formation occurs primarily after day 11. Thus, we created a rat model that developed vitamin A deficiency after embryonic day 11. Ten pregnant rats (5 vitamin A-deficient rats and 5 control rats) were studied. Embryos were collected at embryonic day 18.5 and analyzed histologically.RESULTS:
Eighteen percent of the vitamin A-deficient embryos were alive and demonstrated laryngotracheal cartilage malformation, incomplete separation of the glottis, and/or laryngoesophageal clefts.CONCLUSIONS:
These results document the important role played by vitamin A in laryngeal development.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Complications
/
Vitamin A
/
Vitamin A Deficiency
/
Laryngeal Diseases
/
Larynx
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Ann Otol Rhinol Laryngol
Year:
2007
Type:
Article
Affiliation country:
United States