[Pt(O,O'-acac)(gamma-acac)(DMS)], a new Pt compound exerting fast cytotoxicity in MCF-7 breast cancer cells via the mitochondrial apoptotic pathway.

Muscella, A; Calabriso, N; Fanizzi, F P; De Pascali, S A; Urso, L; Ciccarese, A; Migoni, D; Marsigliante, S

Muscella, A; Calabriso, N; Fanizzi, F P; De Pascali, S A; Urso, L; Ciccarese, A; Migoni, D; Marsigliante, S.

Affiliation

Muscella A; General Pathology Laboratory, Dipartimento di Scienze e Tecnologie Biologiche e Ambientali (DiSTeBA), Università di Lecce, Lecce, Italy.

Br J Pharmacol ; 153(1): 34-49, 2008 Jan.

Article in En | MEDLINE | ID: mdl-18026127

Subject(s)

Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Breast Neoplasms/drug therapy; Mitochondria/drug effects; Organoplatinum Compounds/pharmacology; Breast Neoplasms/pathology; Caspase 3/physiology; Caspase 7/physiology; Cell Line, Tumor; Cisplatin/pharmacology; Female; Humans; Membrane Potentials/drug effects; Proto-Oncogene Proteins c-bcl-2/analysis; bcl-2-Associated X Protein/analysis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organoplatinum Compounds / Breast Neoplasms / Apoptosis / Mitochondria / Antineoplastic Agents Limits: Female / Humans Language: En Journal: Br J Pharmacol Year: 2008 Type: Article Affiliation country: Italy

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