Levels of Smad7 regulate Smad and mitogen activated kinases (MAPKs) signaling and controls erythroid and megakaryocytic differentiation of erythroleukemia cells.

Akel, Salem; Bertolette, Daniel; Petrow-Sadowski, Cari; Ruscetti, Francis W

Akel, Salem; Bertolette, Daniel; Petrow-Sadowski, Cari; Ruscetti, Francis W.

Affiliation

Akel S; Faculty of Allied Health Sciences, Department of Medical Laboratory Sciences, Hashemite University, Zarka, Jordan. sakel@hu.edu.jo

Platelets ; 18(8): 566-78, 2007 Dec.

Article in En | MEDLINE | ID: mdl-18041647

Subject(s)

Cell Differentiation; Erythroid Cells/cytology; Leukemia, Erythroblastic, Acute/pathology; Megakaryocytes/cytology; Signal Transduction; Smad7 Protein/analysis; Activins/metabolism; Autocrine Communication; Gene Expression Regulation; Humans; K562 Cells; MAP Kinase Signaling System; Smad Proteins/metabolism; Smad7 Protein/genetics; Transforming Growth Factor beta/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Megakaryocytes / Signal Transduction / Leukemia, Erythroblastic, Acute / Cell Differentiation / Erythroid Cells / Smad7 Protein Limits: Humans Language: En Journal: Platelets Journal subject: HEMATOLOGIA Year: 2007 Type: Article Affiliation country: Jordan

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