A beta-lactamase reporter assay for monitoring the activation of the smoothened pathway.

Osak, Bella; Fitzgerald, Laura R

Osak, Bella; Fitzgerald, Laura R.

Affiliation

Osak B; Mechanistic and Target Biology, Pfizer, Ann Arbor, MI, USA.

Assay Drug Dev Technol ; 5(6): 785-92, 2007 Dec.

Article in En | MEDLINE | ID: mdl-18052850

Subject(s)

Receptors, G-Protein-Coupled/genetics; beta-Lactamases/genetics; Animals; Cell Count; Cell Line; Cloning, Molecular; Data Interpretation, Statistical; Dimethyl Sulfoxide/metabolism; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Activation; Flow Cytometry; Genes, Reporter/genetics; Indicators and Reagents; Mice; Plasmids/genetics; Receptors, G-Protein-Coupled/agonists; Receptors, G-Protein-Coupled/antagonists & inhibitors; Signal Transduction/drug effects; Signal Transduction/physiology; Smoothened Receptor; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Beta-Lactamases / Receptors, G-Protein-Coupled Limits: Animals Language: En Journal: Assay Drug Dev Technol Journal subject: FARMACOLOGIA Year: 2007 Type: Article Affiliation country: United States

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