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Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
van Es, Michael A; van Vught, Paul W J; Blauw, Hylke M; Franke, Lude; Saris, Christiaan G J; Van den Bosch, Ludo; de Jong, Sonja W; de Jong, Vianney; Baas, Frank; van't Slot, Ruben; Lemmens, Robin; Schelhaas, Helenius J; Birve, Anna; Sleegers, Kristel; Van Broeckhoven, Christine; Schymick, Jennifer C; Traynor, Bryan J; Wokke, John H J; Wijmenga, Cisca; Robberecht, Wim; Andersen, Peter M; Veldink, Jan H; Ophoff, Roel A; van den Berg, Leonard H.
Affiliation
  • van Es MA; Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.
Nat Genet ; 40(1): 29-31, 2008 Jan.
Article in En | MEDLINE | ID: mdl-18084291
ABSTRACT
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.
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Collection: 01-internacional Database: MEDLINE Main subject: Peptide Hydrolases / Potassium Channels / Genetic Predisposition to Disease / Amyotrophic Lateral Sclerosis / Nerve Tissue Proteins Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2008 Type: Article Affiliation country: Netherlands
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Peptide Hydrolases / Potassium Channels / Genetic Predisposition to Disease / Amyotrophic Lateral Sclerosis / Nerve Tissue Proteins Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2008 Type: Article Affiliation country: Netherlands