Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
Nat Genet
; 40(1): 29-31, 2008 Jan.
Article
in En
| MEDLINE
| ID: mdl-18084291
ABSTRACT
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Hydrolases
/
Potassium Channels
/
Genetic Predisposition to Disease
/
Amyotrophic Lateral Sclerosis
/
Nerve Tissue Proteins
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Nat Genet
Journal subject:
GENETICA MEDICA
Year:
2008
Type:
Article
Affiliation country:
Netherlands